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Structure, Mechanism and Engineering of Several Key Enzymes in Biosynthesis and Biocatalysis(中科院上海有机所 周佳海 研究员)

 

  报告题目:Structure, Mechanism and Engineering of Several Key Enzymes in Biosynthesis and Biocatalysis. 

    :周佳海  研究员

  工作单位:中国科学院上海有机化学研究所

  报告时间:201716日(星期五)9:00

  报告地点:行政楼205会议室  

  报告人简介: 

  PROFESSIONAL EXPERIENCE 

  2006-Current  Professor, State Key Laboratory of Bio-organic Chemistry and Natural Products,Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China 

  2000-2001   Assistant Professor, State Key Laboratory of Bio-organic Chemistry and Natural Products,Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,Shanghai, China 

  1993-1995     Research Assistant, Nanjing Chemical Plant, Nanjing, Jiangsu, China 

  EDUCATION   

  1989-1993    B.Sc, Analytical Chemistry, Nanjing University, China - Chemistry  

  1995-2000     Ph.D., Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, China 

  2001-2006     Postdoctoral Fellow, University of Michigan, Ann Arbor, USA 

  RESEARCH INTEREST 

  The research in Zhou laboratory is mainly focused on the structural mechanism and protein engineering of key enzymes in biocatalysis and biosynthesis. Our approaches include a variety of biochemical and biophysical methods, particularly the high-resolution x-ray crystallography and molecular dynamics.  

  RECENT PUBLICATIONS 

  1.       Zhang J., Liu N., Cacho R.A., Gong Z., Liu Z., Qin W., Tang C., Tang Y.#, Zhou J.# (2016) Structural basis of nonribosomal peptide macrocyclization in fungi. Nature Chemical Biology, 12: 1001-1003. 

  2.       Chen W.*, Li Y.*, Li J., Wu L., Li Y., Wang R., Deng Z.#, Zhou J.# (2016) An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis. Protein Cell, 7: 673-683. 

  3.       Zhu H., Xu G., Zhang K., Kong X., Han R., Zhou J.#, Ni Y.# (2016) Crystal structure of tyrosine decarboxylase and key residues in conformational swing and substrate binding. Scientific Reports, 6:27779. 

  4.       Zhou M.*, Xie L.*, Yang Z.*, Zhou J.#, Xie J.# (2016) Lysine succinylation of Mycobacterium tuberculosis isocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics.  Journal of Biomolecular Structure & Dynamics, 19:1-12. 

  5.       Sun Z., Lonsdale R., Ilie A., Li G., Zhou J., Reetz M.T. # (2016) Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple-Code Saturation Mutagenesis of an Alcohol Dehydrogenase. ACS Catalysis, 6:1598-1605. 

  6.       Sun Z., Lonsdale R., Wu L., Li G., Li A., Wang J., Zhou J.#, Reetz M.T.# (2016) Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase.  ACS Catalysis, 6:1590-1597.